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Metabolic Disruption in Long COVID: How Mitochondria, Lactate, and Oxygen Balance May Drive Persistent Fatigue

This paper addresses:   Lactate, Capnia, and Fat Oxidation as Therapeutic Axes for SARS-CoV-2 Spike Protein-Induced Sequelae https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2794-9646 Interpretation: Post-acute COVID-19 syndrome, commonly known as Long COVID, has drawn increasing attention due to persistent symptoms that continue long after infection. Similar symptoms have also been reported in some individuals after COVID-19 vaccination. A growing body of research suggests that many of these cases involve disturbances in the body’s energy metabolism—specifically how cells produce and use energy. One theory proposes that the body’s energy system becomes disrupted at the cellular level. Mitochondria, the power producers of cells, may not function efficiently in some affected individuals. When mitochondria are impaired, the body struggles to generate energy normally. Studies also suggest that the body burns less fat for steady energy and instead relies ...

Ankylosing Spondylitis, Gene Expression, HLA-B27, and the GS145.2 Antibody

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Gene expression is the fundamental biological process through which cells interpret the information encoded in DNA to produce functional molecules, primarily proteins. These proteins perform the essential tasks that allow cells and tissues to function. In practical terms, gene expression acts like a regulatory system—similar to an on/off switch or volume control—ensuring that the right genes are active in the right cells at the right time. Although every cell in the human body contains essentially the same genetic blueprint, different cell types activate different sets of genes. For example, pancreatic beta cells express the gene responsible for producing insulin, whereas lung epithelial cells do not. This selective expression enables cellular specialization and is tightly controlled by multiple regulatory mechanisms. Some people with inflammatory conditions such as ankylosing spondylitis may have increased sensitivity to certain foods, cold temperatures, and physical movements. Cold ...