Posts

Understanding Myelodysplastic Syndromes (MDS): Symptoms, Diagnosis, Genetics, and Treatment

By
What Are Myelodysplastic Syndromes (MDS)? Myelodysplastic syndromes (MDS), also called myelodysplastic neoplasms, are a group of disorders in which the bone marrow does not produce enough healthy, mature blood cells. Instead, blood-forming cells may develop abnormally, fail to mature properly, or die prematurely. Because bone marrow is responsible for producing red blood cells, white blood cells, and platelets, MDS can result in shortages of one or more of these important types of blood cells. MDS varies considerably from person to person. Some forms progress slowly and may require little or no immediate treatment, while others are more aggressive and have a greater risk of progressing to acute myeloid leukemia (AML). Bone Marrow Failure In MDS, abnormal blood-forming cells can interfere with the bone marrow's ability to produce healthy blood cells. Although the bone marrow may contain many developing cells, relatively few mature, functional cells may reach the bloodstream. This pr...
Post a Comment
Read more

mTORC1, Autophagy, and Rapamycin in ME/CFS

By
This discussion is an extension of the previously described in summary the consequences of chronic mTOR activation in Chronic activation of the mTOR pathway has significant implications for cellular and organismal health : previous article on chronic mTOR activation . At the Community Symposium on the Molecular Basis of ME/CFS , on 9/11/2026, David Kaufman presented a proposed connection between mTORC1 activation, impaired autophagy, mitochondrial dysfunction, inflammation, and ME/CFS , together with the possibility of using rapamycin (sirolimus) to modify this pathway. mTORC1 and autophagy mTORC1 is an important cellular sensor of nutrients, energy availability, growth signals, and stress. When mTORC1 is active, it promotes growth and protein synthesis while suppressing autophagy . Autophagy is the cell's recycling and quality-control system: Damaged proteins/mitochondria → autophagosome → lysosome → degradation → recycling A particularly important component is mitophagy ...
Post a Comment
Read more