Metabolic Disruption in Long COVID: How Mitochondria, Lactate, and Oxygen Balance May Drive Persistent Fatigue
This paper addresses: Lactate, Capnia, and Fat Oxidation as Therapeutic Axes for SARS-CoV-2 Spike Protein-Induced Sequelae https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2794-9646 Interpretation: Post-acute COVID-19 syndrome, commonly known as Long COVID, has drawn increasing attention due to persistent symptoms that continue long after infection. Similar symptoms have also been reported in some individuals after COVID-19 vaccination. A growing body of research suggests that many of these cases involve disturbances in the body’s energy metabolism—specifically how cells produce and use energy. One theory proposes that the body’s energy system becomes disrupted at the cellular level. Mitochondria, the power producers of cells, may not function efficiently in some affected individuals. When mitochondria are impaired, the body struggles to generate energy normally. Studies also suggest that the body burns less fat for steady energy and instead relies ...