Iron Overload, Thyroid Dysfunction, and Severe Immune Reactions: Understanding the Link
High iron levels can affect multiple systems in the body, including the thyroid and immune system. This article explores how iron overload—commonly caused by conditions like hemochromatosis —can impact thyroid function, contribute to autoimmune diseases, and in rare cases, complicate severe inflammatory disorders such as Stevens-Johnson Syndrome (SJS) and Hemophagocytic Lymphohistiocytosis (HLH) . SJS, HLH, and the Role of Iron Overload Stevens-Johnson Syndrome (SJS) is a severe, potentially life-threatening skin and mucous membrane reaction, often triggered by medications. In rare instances, SJS can progress into Hemophagocytic Lymphohistiocytosis (HLH) , a critical condition involving excessive immune system activation. One reported case involved SJS complicated by HLH in a patient with underlying hemochromatosis . The individual exhibited SJS-like skin symptoms, suffered a stroke, and was later diagnosed with HLH. This case highlights the potential ...