Genetics and Epigenetics in Neuromuscular Disorders: Key Genes, Therapy Effects, and Latest Research

By SWA

1. Can psychotherapy change genes?

Psychotherapy can influence gene expression through epigenetic mechanisms, but it does not alter the DNA sequence itself. Studies show that therapies like cognitive behavioral therapy (CBT) can regulate stress responses by affecting epigenetic modifications in genes related to stress, anxiety, or depression (e.g., the FKBP5 gene (99 citations)), which is involved in stress hormone regulation).

2. Is ME/CFS genetic or epigenetic?

ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) has both genetic and epigenetic components:

  • Genetic: Studies suggest familial clustering, and certain genes related to immune function and energy production may play a role.
  • Epigenetic: Changes in DNA methylation and gene expression may influence ME/CFS, particularly in pathways linked to energy metabolism, the immune system, and the nervous system.

3. SMA: Genes SMN1 and SMN2?

Yes, spinal muscular atrophy (SMA) is caused by mutations in the SMN1 gene. The SMN2 gene is a copy of SMN1 but produces less functional SMN protein. The number of SMN2 copies affects disease severity—more copies can lead to milder symptoms.

(Source: Understanding Spinal Muscular Atrophy)

4. Dysferlin: DYSF gene?

Yes, the DYSF gene encodes the dysferlin protein, which plays a crucial role in repairing muscle cell membranes. Mutations in the DYSF gene lead to dysferlinopathies, such as Limb-Girdle Muscular Dystrophy Type 2B (LGMD2B) and Miyoshi Myopathy.

(Source: Dysferlin Protein: Key Roles & Locations)

5. PPS: Neuromuscular function, inflammation, and nerve regeneration

Post-Polio Syndrome (PPS) is a late effect of poliomyelitis, affecting neuromuscular function, inflammatory processes, and nerve regeneration. While genetic and epigenetic factors may influence disease severity, no single genetic cause has been identified.

(Source: Post-Polio Syndrome (PPS) – Summary and Key Points)

© 2000-2025 Sieglinde W. Alexander. All writings by Sieglinde W. Alexander have a fife year copy right. Library of Congress Card Number: LCN 00-192742 ISBN: 0-9703195-0-9

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