Staphylococcus aureus bacteremia (SAB)

By SWA

S. aureus can also cause serious infections such as pneumonia (infection of the lungs) or bacteremia (bloodstream infection). Symptoms of these infections include:
difficulty breathing, malaise, fever, or chills. https://www.health.state.mn.us/diseases/staph/basics.html

How common is Staphylococcus aureus bacteremia?

Summary: Staphylococcus aureus bacteremia (SAB) is an important infection with an incidence rate ranging from 20 to 50 cases/100,000 population per year. Between 10% and 30% of these patients will die from SAB. https://www.health.state.mn.us/diseases/staph/basics.html

What happens if Staphylococcus aureus gets into the bloodstream?

The presence of S. aureus in the bloodstream (bacteremia) can lead to the development of sepsis - a systemic inflammatory response to infection. A typical feature of sepsis is the paradoxical immunosuppressive response that is sometimes concurrent with inflammation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244392/

What are the early symptoms of Staphylococcus?

Symptoms of a staph skin infection can include:

A painful red lump or bump on the skin. This is often a boil or carbuncle (cluster of boils). ...    Hot, red and swollen skin. This could be an infection called cellulitis. ...
Sores, crusts or blisters. This could be impetigo, which often affects the face. ...
Sore, red eyelids or eyes. https://www.nhs.uk/conditions/staphylococcal-infections/

Ceftobiprole for Treatment of Complicated Staphylococcus aureus Bacteremia
https://www.nejm.org/doi/full/10.1056/NEJMoa2300220

What class of drug is ceftobiprole?

Ceftobiprole belongs to the cephalosporin drug class and possesses a wide spectrum of antibacterial activity against Gram-positive and Gram-negative pathogens including MRSA and penicillin-resistant S. https://www.sciencedirect.com/topics/medicine-and-dentistry/ceftobiprole-medocaril

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