Psoriasis Causes Beyond Immune Deficiency and Nutritional Deficiencies

By SWA

Psoriasis is a complex, chronic skin condition that goes beyond simple immune deficiency or nutritional deficiencies. While immune dysregulation and deficiencies in minerals, vitamins, and proteins can exacerbate the condition, there are numerous other factors that contribute to the development and severity of psoriasis. Here’s a deeper dive into these causes and triggers, including the roles of genetics, lifestyle factors, environmental triggers, and specific hormones.

1. Genetics: A Strong Predisposition

Psoriasis often runs in families, indicating a strong genetic component. Research has identified specific genes associated with psoriasis, and having a family member with the condition significantly increases one’s risk. Certain gene variations, particularly those involved in immune system function, can predispose individuals to an overactive immune response that targets skin cells, leading to the rapid cell turnover seen in psoriasis.

2. Environmental Triggers: Stress, Injury, and Medications

External factors can trigger or exacerbate psoriasis flare-ups. Common environmental triggers include:

  • Stress: High levels of stress can lead to elevated cortisol (the "stress hormone"), which may initially suppress inflammation but, over time, disrupts immune function and can lead to worsening symptoms.
  • Skin Injury: Physical trauma to the skin, such as cuts, scrapes, or even sunburn, can induce psoriasis patches in a phenomenon known as the Koebner effect.
  • Infections: Infections, particularly strep throat, can trigger certain types of psoriasis, such as guttate psoriasis, especially in young people.
  • Medications: Certain medications, including lithium, beta-blockers, and anti-malarial drugs, have been associated with psoriasis flare-ups.

3. Lifestyle Factors: Smoking, Alcohol, and Obesity

Lifestyle choices can significantly influence psoriasis severity:

  • Smoking: Tobacco use is associated with a higher risk of psoriasis, and smoking can worsen symptoms.
  • Alcohol: Excessive alcohol consumption can exacerbate psoriasis and interfere with certain treatments.
  • Obesity: Higher body weight is linked to more severe psoriasis. Fat cells produce inflammatory cytokines, which can increase systemic inflammation, thereby worsening symptoms. Additionally, the skin folds in obese individuals may be more prone to irritation and psoriasis patches.

4. Hormonal Changes: The Impact of Hormones on Psoriasis

Hormonal fluctuations can play a significant role in psoriasis, particularly in women. Changes in hormone levels during puberty, pregnancy, menstruation, and menopause can lead to variations in psoriasis symptoms. Here’s a closer look at specific hormones and how they impact psoriasis:

  • Estrogen: Estrogen has anti-inflammatory properties. Higher estrogen levels, such as those seen during pregnancy, often improve psoriasis symptoms. However, symptoms can worsen postpartum when estrogen levels drop. Similarly, during menopause, when estrogen decreases, many women experience a worsening of their psoriasis.

  • Progesterone: This hormone works with estrogen to regulate the menstrual cycle. Some women report increased psoriasis symptoms in the luteal phase of their cycle, when progesterone is higher. Evidence suggests that low levels of progesterone might worsen autoimmune responses, but the relationship with psoriasis is still under investigation.

  • Testosterone: While testosterone is primarily known as a male hormone, it is present in both men and women. Higher testosterone levels are associated with thicker skin and greater collagen production. Some research suggests that low testosterone levels in men could worsen psoriasis, but more studies are needed to fully understand this relationship.

  • Cortisol: Often called the “stress hormone,” cortisol has a complex role in psoriasis. Short bursts of cortisol can reduce inflammation, but chronic stress leads to prolonged cortisol release, which can cause cortisol resistance in the body. This resistance means the body stops responding to cortisol’s anti-inflammatory effects, leading to unchecked inflammation and potential psoriasis flare-ups.

  • Prolactin: Known for its role in milk production, prolactin also influences immune system function. Elevated prolactin levels, such as those that occur during pregnancy and breastfeeding, are associated with increased inflammation, potentially exacerbating psoriasis.

  • Insulin and Insulin-like Growth Factor 1 (IGF-1): Insulin resistance, often linked to obesity and metabolic syndrome, can worsen psoriasis by promoting systemic inflammation. IGF-1, which supports cell growth and differentiation, is often elevated in those with insulin resistance, contributing to the rapid skin cell turnover seen in psoriasis.

  • Thyroid Hormones (T3 and T4): These hormones regulate metabolism and immune system function. Hypothyroidism, or low thyroid function, has been associated with a higher risk of psoriasis. Impaired thyroid function can disrupt immune regulation, potentially increasing inflammation and worsening psoriasis symptoms.

5. Inflammatory Response: An Autoimmune Misfire

Psoriasis is classified as an autoimmune disease, where the immune system mistakenly attacks healthy skin cells. This overactive immune response leads to a rapid turnover of skin cells, resulting in the characteristic red, scaly patches. Unlike a simple immune deficiency, psoriasis involves an immune system that is hyperactive and imbalanced, leading to chronic inflammation in the skin and sometimes in other parts of the body, such as the joints (in psoriatic arthritis).

6. Gut Health and Microbiome Imbalance

Emerging research suggests that the gut microbiome plays a significant role in immune system health, potentially influencing autoimmune diseases like psoriasis. Dysbiosis, or an imbalance of gut bacteria, has been linked to systemic inflammation. Some scientists believe that a compromised gut barrier (or “leaky gut”) could allow bacterial toxins to enter the bloodstream, triggering an immune response that may worsen psoriasis. While more research is needed, some individuals with psoriasis find that dietary changes aimed at improving gut health can positively affect their symptoms.

Integrative Approaches to Managing Psoriasis

Given the complex nature of psoriasis, an integrative approach that addresses these various factors can be beneficial. Here are some ways to manage the condition holistically:

  1. Hormone Regulation: Women experiencing severe symptom fluctuations related to their menstrual cycle or menopause may benefit from hormone therapies or birth control pills. For men with low testosterone, testosterone replacement therapy might be considered.

  2. Stress Management: Chronic stress can exacerbate psoriasis. Techniques like mindfulness, meditation, exercise, and even cognitive-behavioral therapy (CBT) can help lower cortisol levels and reduce the impact of stress on the skin.

  3. Dietary Considerations: An anti-inflammatory diet rich in omega-3 fatty acids (found in fish, flaxseeds, and walnuts) can help counteract inflammation. Reducing refined carbohydrates can improve insulin sensitivity, potentially benefiting those with insulin resistance.

  4. Lifestyle Modifications: Maintaining a healthy weight, avoiding smoking and excessive alcohol, and staying physically active are important lifestyle factors that can reduce systemic inflammation and improve psoriasis symptoms.

  5. Gut Health Support: Supporting a healthy gut microbiome through diet, probiotics, and reducing processed foods may also benefit psoriasis patients. Some individuals find that an anti-inflammatory or low-sugar diet helps manage their symptoms, although more research is needed in this area.

  6. Regular Monitoring of Hormone Levels: For those with underlying thyroid issues or insulin resistance, regular monitoring and treatment adjustments may help control psoriasis flare-ups.

Final Thoughts

Psoriasis is influenced by a combination of genetic, environmental, hormonal, and lifestyle factors. While the condition cannot be cured, understanding these diverse triggers can help individuals manage their symptoms more effectively. If hormones are suspected to be a significant trigger, working with a healthcare provider to create a tailored treatment plan that addresses both psoriasis symptoms and hormonal imbalances can make a substantial difference.

Ultimately, an integrative approach that considers lifestyle changes, stress management, dietary adjustments, and medical therapies can empower individuals to manage their psoriasis and improve their quality of life.

Here are some references from reputable sources that can provide more in-depth information on the various causes, triggers, and management strategies for psoriasis.

1. Genetics and Psoriasis

2. Environmental Triggers and Psoriasis

3. Lifestyle Factors: Smoking, Alcohol, and Obesity

4. Hormonal Changes and Psoriasis

  • National Psoriasis Foundation (NPF): Provides information on how hormonal changes during puberty, pregnancy, and menopause can impact psoriasis.

  • Dermatology Research and Practice: A scientific journal article reviewing hormonal influences on psoriasis, especially regarding estrogen, progesterone, and cortisol.

5. Inflammatory Response and Autoimmunity

6. Gut Health and Psoriasis

7. Integrative and Holistic Management of Psoriasis

8. Hormones and Psoriasis – Detailed Mechanisms

  • Dermato-Endocrinology: Article exploring the effects of various hormones like estrogen, progesterone, testosterone, cortisol, prolactin, and thyroid hormones on psoriasis.

    • Reference: "Hormonal influences on psoriasis in women: Some differences between estrogen and progesterone," Dermato-Endocrinology, 2012. https://doi.org/10.4161/derm.20481

  • Journal of the European Academy of Dermatology and Venereology (JEADV): Research on cortisol dysregulation and its effects on autoimmune diseases, including psoriasis.

These references provide additional insights into the genetic, hormonal, lifestyle, and environmental factors associated with psoriasis. If you're interested in learning more about any specific aspect, these resources should be a good starting point!

 © 2000-2025 Sieglinde W. Alexander. All writings by Sieglinde W. Alexander have a fife year copy right.
Library of Congress Card Number: LCN 00-192742
ISBN: 0-9703195-0-9

 

Comments

Post a Comment

Popular posts from this blog

Toxic Skin Condition Post-mRNA COVID-19 Vaccination

By SWA
Image
Identifying Severe Skin Conditions Post-Vaccination Following administration of the BioNTech mRNA vaccine, a small subset of individuals may develop severe and complex reactions. These reactions are often misdiagnosed or misunderstood due to their rarity and diverse presentation. This essay examines a case characterized by severe skin conditions, systemic symptoms, and complications such as hypercalcemia and crystal formation. It highlights the need for accurate diagnosis, holistic management, and increased awareness of these rare but significant vaccine-related adverse events. Initial Symptoms and Misdiagnoses Severe symptoms began shortly after the first dose of the BioNTech vaccine, initially presenting as petechiae, diagnosed by a rheumatologist. However, following the second dose, symptoms rapidly escalated, resulting in intense burning pain and thinning of the skin. The skin on the legs and thighs became paper-thin and could tear with the slightest touch, with the affected area e...
Read more

Dysferlin Protein: Key Roles, Genetic Locations

By SWA
Image
The purpose of this article is to share and discuss the details of a new discovery, which is highlighted within: CRISPR-Cas9: A Breakthrough Tool to Repair the DYSF Gene The dysferlin protein plays an essential role in maintaining the integrity of muscle cell membranes, particularly in tissues that endure significant mechanical stress, such as skeletal and cardiac muscles . Encoded by the DYSF gene , dysferlin is indispensable for repairing damaged cell membranes after injury caused by muscle contraction or external forces. This article explores the main locations where dysferlin is produced, its role in muscle repair, and supportive nutritional and therapeutic strategies for individuals with dysferlin deficiency, such as those affected by dysferlinopathies (e.g., Limb-Girdle Muscular Dystrophy Type 2B or Miyoshi Myopathy). Currently, there is no definitive answer as to why the severity of dysferlin protein expression or depletion varies. Do pathogens play a role in the methylation o...
Read more

Is ME CFS connected to Spinal Muscular Atrophy (SMA) or Post Polio?

By SWA
Image
Today, I understand why Spinal Muscular Atrophy (SMA) received little attention, particularly in the mid-50s. This complex and debilitating genetic illness was poorly understood, and patients' symptoms were often minimized or even dismissed. For more information, please visit the Spinal Muscular Atrophy (SMA) page on MalaCards . Even now, many neurologists lack detailed knowledge of SMA, and comprehensive examinations mentioned in research are rarely pursued. In 2008, while investigating permanent adrenal insufficiency, an MRI ordered by my endocrinologist unexpectedly revealed Chiari Malformation II. However, surgery in 2009 brought no improvement. In 2010, a DNA test showed a genetic marker in the ACTN3 gene: https://www.malacards.org/search/results?q=ACTN3%20gene%20and%20Spinal%20Muscular%20Atrophy%20(SMA) A 2015 MRI revealed ankylosing spondylitis, multiple Tarlov cysts, stenosis at L4 and L5, spinal canal narrowing, and widespread degenerative changes. Surgery on L4 and L5 ...
Read more