Note: The impact of COVID-19 on the endocrine system

By SWA

The impact of COVID-19 on the endocrine system remains one of the most neglected areas in both research and clinical practice.
Despite Dr. Danielle Beckman's recognition “I'm not familiar with this study, but I will check it out! But honestly, this region can be very vulnerable to viral infection, as the anterior pituitary gland is located outside of the blood-brain barrier, so specific damage there would not be surprising”, (https://x.com/DaniBeckman/status/1849475969788354724) this connection is largely overlooked by the medical community.

While some studies have highlighted the endocrine inflammatory response following COVID-19 infection or vaccination, healthcare providers often fail to consider potential disruptions in endocrine function. As a result, unless hormone-informed patients specifically request tests for hormones such as cortisol or catecholamines, these assessments are frequently dismissed as unnecessary. This oversight creates a critical gap in understanding the full spectrum of COVID-19’s long-term effects on the endocrine system and overall health.

“Studies have shown that the pituitary, thyroid, pancreas, adrenals and gonads can all be affected by the virus, as they all express the angiotensin-converting enzyme 2 (ACE2) receptor which facilitates SARS-CoV-2 attachment and therefore induces cell damage [5,6,7,8,9].”
https://link.springer.com/article/10.1007/s12020-022-03119-3

Unfortunately, some publications on COVID-19 and the endocrine system remain uncorrected, potentially perpetuating misconceptions.
For example, the article titled “COVID-19 and the Endocrine System: A Review of the Current Information and Misinformation,” published on March 11, 2022
(https://www.mdpi.com/2036-7449/14/2/23), states in its conclusions: “Misinformation about COVID-19 vaccination, such as infertility in men and adverse effects on pregnancy in women, are not substantiated by the data available.”

While this statement seeks to address and dispel fears about reproductive health impacts, it may oversimplify complex concerns that still warrant further investigation. Emerging evidence suggests there may be nuanced effects of COVID-19 infection—and potentially the vaccine—on hormone regulation and reproductive health, yet these areas are often under-researched or dismissed prematurely. This highlights the need for a more balanced and evidence-based approach in assessing potential long-term endocrine impacts of COVID-19 and vaccination, rather than downplaying concerns without thorough study.

© 2000-2025 Sieglinde W. Alexander. All writings by Sieglinde W. Alexander have a fife year copy right.
Library of Congress Card Number: LCN 00-192742 ISBN: 0-9703195-0-9

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