Medications to Avoid in Blood Disorders: A Focus on ADAMTS13 Deficiency, Erythrocytosis, and Polycythemia Vera
When managing blood disorders such as ADAMTS13 deficiency , high erythrocytosis , or polycythemia vera (PV) , understanding which medications to avoid is critical. Certain drugs can worsen symptoms, trigger relapses, or increase the risk of serious complications such as thrombosis or leukemia. This article outlines key medications to avoid for each condition and the rationale behind these recommendations. ADAMTS13 Deficiency (Thrombotic Thrombocytopenic Purpura - TTP) ADAMTS13 deficiency, especially in TTP, can be either inherited (congenital) or acquired. Medications can act as direct triggers for acquired TTP, particularly in individuals already at risk. Medications to Avoid: Antiplatelet Drugs : Ticlopidine and clopidogrel (Plavix) are known causes of drug-induced TTP and should be avoided. Chemotherapy Agents : Mitomycin C and cisplatin may induce TTP by damaging the vascular endothelium or triggering immune responses. Hormonal Therapies : Estrogen-containing birt...