B6 deficiency

By SWA

The ALPL gene plays a role in breaking down vitamin B6 from complex to simpler forms. It produces enzymes that help in clearance of B6. A particular variant (type) of the gene can cause 12-18% lowered vitamin B6 rates in the body. Individuals with this type are likely to require more vitamin B6 levels.
https://www.xcode.life/genes-and-nutrition/genes-vitamin-b6-requirements/

ALDH7A1 (also referred to as PDE-ALDH7A1, ALDH7A1 deficiency, or antiquitin deficiency), PNPO deficiency, and PLPBP deficiency are the most common genetic causes of vitamin B6-dependent and vitamin B6-responsive epilepsies presenting in neonates, infants, and children ...
https://www.ncbi.nlm.nih.gov/books/NBK589231/

Vitamin B6 deficiency is often associated with other vitamin B deficiencies, such as folic acid and vitamin B12. Low plasma levels of active vitamin B6 are found in individuals with chronic alcohol dependence, obesity, and protein-energy malnutrition.
https://www.ncbi.nlm.nih.gov/books/NBK470579/

What autoimmune disease causes low B6 levels?
Certain conditions can increase the risk of developing a deficiency by interfering with the absorption of vitamin B6: Kidney disease. Autoimmune intestinal disorders like celiac disease, ulcerative colitis, and Crohn's disease. Autoimmune inflammatory disorders such as rheumatoid arthritis.
 
Does B6 deplete dopamine?
Vitamin B6 is a key player in the synthesis of many neurotransmitters, including GABA, serotonin, dopamine, noradrenalin, and histamine. B6 thus helps increase brain serotonin and dopamine levels, decreasing symptoms of anxiety, depression, fatigue, and pain.
https://www.mindlabpro.com/blogs/nootropics/b6-and-dopamine

B6 in food: https://www.hsph.harvard.edu/nutritionsource/vitamin-b6/

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