Mast cell activation symptoms are prevalent in Long-COVID

By SWA

https://www.ijidonline.com/article/S1201-9712(21)00751-7/fulltext

Systemic mastocytosis and Long-COVID are two distinct medical conditions, but they can share some similarities in terms of their impact on an individual's health and quality of life. Here's an overview of each condition and how they may relate:

  1. Systemic Mastocytosis:

    • As previously explained, systemic mastocytosis is a rare condition characterized by an abnormal accumulation of mast cells in various organs and tissues throughout the body.
    • Symptoms of systemic mastocytosis can include skin problems, gastrointestinal issues, respiratory problems, low blood pressure, bone pain, headaches, and fatigue. These symptoms are often triggered by various stimuli and can range from mild to severe.
    • Systemic mastocytosis is a chronic condition that can require long-term management and may have different subtypes with varying levels of severity.
    • While systemic mastocytosis is primarily related to mast cell dysfunction and activation, it is not directly associated with COVID-19. However, individuals with systemic mastocytosis may be at risk for complications if they contract COVID-19 due to their underlying immune and allergic sensitivities.

  2. Long-COVID (Post-Acute Sequelae of SARS-CoV-2 Infection or PASC):

    • Long-COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), refers to a constellation of symptoms and health issues that persist for weeks or months after the acute phase of a COVID-19 infection has resolved.
    • The symptoms of Long-COVID can vary widely and may include fatigue, shortness of breath, chest pain, brain fog, joint pain, and a range of neurological and psychological symptoms.
    • Long-COVID is primarily associated with prior COVID-19 infection, and it can affect individuals who had mild or severe cases of the virus. The exact mechanisms behind Long-COVID are not fully understood but may involve a combination of viral persistence, immune dysregulation, and tissue damage.
    • Treatment for Long-COVID typically focuses on managing the specific symptoms and may involve a multidisciplinary approach, including physical therapy, cognitive-behavioral therapy, and medication to address specific symptoms.

While systemic mastocytosis and Long-COVID are distinct conditions, they can both have a profound impact on an individual's well-being and quality of life. Some individuals with systemic mastocytosis may experience worsened symptoms or complications if they contract COVID-19, which underscores the importance of vaccination and infection prevention measures for this population. Additionally, the presence of Long-COVID symptoms may further complicate the overall health management of individuals with underlying medical conditions like systemic mastocytosis. In such cases, a comprehensive and individualized approach to healthcare is essential to address the unique needs and challenges of each patient.

Comments

Post a Comment

Popular posts from this blog

Toxic Skin Condition Post-mRNA COVID-19 Vaccination

By SWA
Image
Identifying Severe Skin Conditions Post-Vaccination Following administration of the BioNTech mRNA vaccine, a small subset of individuals may develop severe and complex reactions. These reactions are often misdiagnosed or misunderstood due to their rarity and diverse presentation. This essay examines a case characterized by severe skin conditions, systemic symptoms, and complications such as hypercalcemia and crystal formation. It highlights the need for accurate diagnosis, holistic management, and increased awareness of these rare but significant vaccine-related adverse events. Initial Symptoms and Misdiagnoses Severe symptoms began shortly after the first dose of the BioNTech vaccine, initially presenting as petechiae, diagnosed by a rheumatologist. However, following the second dose, symptoms rapidly escalated, resulting in intense burning pain and thinning of the skin. The skin on the legs and thighs became paper-thin and could tear with the slightest touch, with the affected area e...
Read more

Dysferlin Protein: Key Roles, Genetic Locations

By SWA
Image
The purpose of this article is to share and discuss the details of a new discovery, which is highlighted within: CRISPR-Cas9: A Breakthrough Tool to Repair the DYSF Gene The dysferlin protein plays an essential role in maintaining the integrity of muscle cell membranes, particularly in tissues that endure significant mechanical stress, such as skeletal and cardiac muscles . Encoded by the DYSF gene , dysferlin is indispensable for repairing damaged cell membranes after injury caused by muscle contraction or external forces. This article explores the main locations where dysferlin is produced, its role in muscle repair, and supportive nutritional and therapeutic strategies for individuals with dysferlin deficiency, such as those affected by dysferlinopathies (e.g., Limb-Girdle Muscular Dystrophy Type 2B or Miyoshi Myopathy). Currently, there is no definitive answer as to why the severity of dysferlin protein expression or depletion varies. Do pathogens play a role in the methylation o...
Read more

Is ME CFS connected to Spinal Muscular Atrophy (SMA) or Post Polio?

By SWA
Image
Today, I understand why Spinal Muscular Atrophy (SMA) received little attention, particularly in the mid-50s. This complex and debilitating genetic illness was poorly understood, and patients' symptoms were often minimized or even dismissed. For more information, please visit the Spinal Muscular Atrophy (SMA) page on MalaCards . Even now, many neurologists lack detailed knowledge of SMA, and comprehensive examinations mentioned in research are rarely pursued. In 2008, while investigating permanent adrenal insufficiency, an MRI ordered by my endocrinologist unexpectedly revealed Chiari Malformation II. However, surgery in 2009 brought no improvement. In 2010, a DNA test showed a genetic marker in the ACTN3 gene: https://www.malacards.org/search/results?q=ACTN3%20gene%20and%20Spinal%20Muscular%20Atrophy%20(SMA) A 2015 MRI revealed ankylosing spondylitis, multiple Tarlov cysts, stenosis at L4 and L5, spinal canal narrowing, and widespread degenerative changes. Surgery on L4 and L5 ...
Read more