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Showing posts from September, 2023

The roll off monocytes, their short lifespan and apoptosis, or differentiate into tissue-resident macrophages.

  Monocytes are a type of white blood cell, also known as leukocytes, that play a crucial role in the immune system's defense against infections and other diseases. They are part of the body's innate immune system, which provides immediate, non-specific protection against a wide range of pathogens like bacteria, viruses, and fungi. Here are some key points to understand about monocytes: Origin : Monocytes are produced in the bone marrow from hematopoietic stem cells. These stem cells differentiate into various types of blood cells, including monocytes. Circulation : Once formed, monocytes are released into the bloodstream, where they circulate throughout the body. Phagocytosis : Monocytes are primarily known for their phagocytic activity, which means they can engulf and ingest foreign particles such as bacteria, viruses, and cellular debris. This process helps remove these potentially harmful substances from the body.   Immune Response : Monocytes are part of the first line of...

A summary of Von Willebrand factor (VWF), fibrin, and fibrinogen

Von Willebrand factor (VWF), fibrin, and fibrinogen are essential components of the blood clotting process, each with distinct functions: Fibrinogen Production: Fibrinogen is produced primarily in the liver, specifically by hepatocytes (liver cells). It is synthesized and released into the bloodstream. The production of fibrinogen is regulated by various factors, including cytokines and hormones, such as interleukin-6 (IL-6) and interleukin-1 (IL-1). These factors can stimulate the liver to produce more fibrinogen in response to inflammation or injury. Fibrinogen is considered a soluble plasma protein, meaning it circulates in the blood in an inactive form.  Von Willebrand Factor (VWF): VWF facilitates platelet adhesion and aggregation. It acts as a bridge between platelets and damaged blood vessel walls. VWF is produced by endothelial cells and megakaryocytes and plays a role in stabilizing factor VIII. Fibrinogen: Fibrinogen is a soluble plasma protein produced in the liver. It i...

Amyloidosis explained

Amyloidosis is a rare and complex group of diseases characterized by the abnormal accumulation of amyloid protein in various organs and tissues of the body. Amyloid is an insoluble, fibrous protein that can build up in different parts of the body, disrupting normal tissue structure and function. There are several types of amyloidosis, each associated with different proteins and organ systems affected. Here are some key points about amyloidosis: Types of Amyloidosis: There are several types of amyloidosis, but the most common ones include: AL Amyloidosis (Immunoglobulin Light Chain Amyloidosis): This type is associated with the accumulation of abnormal immunoglobulin light chain proteins, often produced by abnormal plasma cells in the bone marrow. It can affect various organs, including the heart, kidneys, nervous system, and digestive tract. AA Amyloidosis (Amyloid A Protein Amyloidosis): This type is linked to the buildup of amyloid A protein, which is usually a response to chroni...

What are the consequences of too much hydrogel in the blood?

Recreant publication regarding elevated hydrogel or PEG was detected in the Covid-19 vaccine that led me to researging the potential harmful consequences.  First findings: The introduction of too much hydrogel into the bloodstream can have several potential consequences, depending on the type of hydrogel, its properties, and the amount introduced. Here are some possible consequences: Hemodilution : Large amounts of hydrogel in the bloodstream can dilute the blood, which may affect the balance of electrolytes, blood cells, and proteins in the blood. Hemodilution can reduce the blood's ability to carry oxygen and nutrients efficiently, potentially leading to symptoms of anemia and impaired circulation. Clotting and Thrombosis : Some hydrogel materials can trigger the activation of the clotting cascade, leading to the formation of blood clots. These clots can block blood vessels, which may result in serious conditions such as deep vein thrombosis (DVT), pulmonary embolism, or stroke. ...

Elevated count of erythrocytes, suggesting a potential condition of polycythemia vera.

An elevated count of erythrocytes , also known as red blood cells (RBCs), may suggest a potential condition known as polycythemia vera (PV). PV is a rare, chronic blood disorder characterized by the overproduction of red blood cells in the bone marrow. This overproduction can lead to an increased number of RBCs in the bloodstream, which can have various health implications. Here's an explanation of an elevated RBC count and its association with PV: Normal RBC Count : In a healthy individual, the number of RBCs in the blood is within a certain range, typically measured in millions of cells per microliter (million/µL). The normal range can vary slightly depending on the laboratory and the individual's age and sex. An elevated RBC count is generally considered when the number of RBCs exceeds the upper limit of this range. Polycythemia Vera (PV) : PV is a type of myeloproliferative neoplasm (MPN) in which the bone marrow produces an excessive number of blood cells, including RBCs, ...