Blood Tests: ANP and Related Biomarkers

By SWA

Testing for cardiac ANP (atrial natriuretic peptide) dysregulation involves both direct and indirect methods to assess abnormal hormone levels and their physiological effects. Here's a comprehensive overview of how clinicians evaluate suspected ANP-related disorders, such as cardiac tumors, heart failure, or hyponatremia due to hormone overproduction.

Related:

Vorhof-Herztumore und Hormonstörungen: Wenn das Herz die Psyche beeinflusst
https://swaresearch.blogspot.com/2025/06/atrial-heart-tumors-and-hormonal.html

1. Blood Tests: ANP and Related Biomarkers

Atrial Natriuretic Peptide (ANP)

  • Direct measurement of ANP in blood plasma.

  • Elevated levels suggest atrial stretch, volume overload, or ANP-secreting tumors.

  • May be unstable due to short half-life, so it's less commonly used in routine clinical practice.

NT-proANP (N-terminal pro-ANP)

  • A more stable fragment of the ANP precursor.

  • Better for diagnostic purposes, especially for chronic monitoring.

BNP (B-type Natriuretic Peptide) and NT-proBNP

  • Frequently used as surrogates, especially in heart failure workups.

  • BNP is secreted mainly by the ventricles but still correlates with volume overload.

  • May rise in conjunction with ANP in many cardiac conditions.

 Where to get it: These tests are usually available through specialized hospital labs or academic centers. Standard blood draw is sufficient.

Reference Ranges (may vary by lab):

BiomarkerNormal Range
ANP                < 100 pg/mL
NT-proANP                < 300 pmol/L
BNP                < 100 pg/mL
NT-proBNP                < 125 pg/mL (under age 75)

© 2000-2025 Sieglinde W. Alexander. All writings by Sieglinde W. Alexander have a fife year copy right. Library of Congress Card Number: LCN 00-192742

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