Q and A: about health and research

Thiamine, also known as vitamin B1 , is an essential water-soluble vitamin involved in many crucial metabolic processes. It plays a central role in converting carbohydrates into energy and is vital for the proper functioning of the nervous system , muscles , and heart . Since the body cannot produce or store large amounts of thiamine, a continuous dietary supply is needed to prevent deficiency. A deficiency in thiamine can lead to serious health complications, particularly affecting the nervous system and cardiovascular system , and in severe cases, it can mimic symptoms of other neurological disorders such as ALS. Below, we explore the causes, symptoms, and implications of thiamine deficiency in detail. How Thiamine Works in the Body Thiamine is a coenzyme in several metabolic processes, particularly in the energy production pathways of glucose metabolism. It is required for: ATP Production : Thiamine is critical for the enzymatic processes that produce adenosine triphosphate (ATP), ...

This is a  collection of skeletal muscle weakness-related illnesses. β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle   The clinical benefit of ketosis has historically and almost exclusively centered on neurological conditions, lending insight into how ketones alter mitochondrial function in neurons. However, there is a gap in our understanding of how ketones influence mitochondria within skeletal muscle cells.  https://pubmed.ncbi.nlm.nih.gov/30071599/ The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from fatty acids and represents an essential carrier of energy from the liver to peripheral tissues when the supply of glucose is too low for the body's energetic needs . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640868/  Post-polio syndrome and muscle weakness Post-polio syndrome (PPS) is a disorder of the nerves and muscles. It happens in some people many years after they have had polio. PPS ma...