Severe Immune Thrombocytopenia (ITP)
Definition Severe Immune Thrombocytopenia (ITP) is an autoimmune disorder characterized by: A platelet count typically < 30,000/µL (often used clinically for “severe” disease) Clinically significant bleeding , such as: Mucosal hemorrhages (e.g., nosebleeds, gum bleeding) Petechiae (small red spots on the skin) In ITP, the immune system produces antibodies that destroy platelets, increasing the risk of serious internal bleeding . Latest research: CD19 CAR-T therapy induces remission in refractory autoimmune hemolytic anemia with ITP and antiphospholipid syndrome https://www.cell.com/med/fulltext/S2666-6340(26)00078-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666634026000784%3Fshowall%3Dtrue Clinical Features Common Symptoms Mucosal bleeding Petechiae Purpura (easy bruising) --------------------------------------------------------- Additional Patient-Reported Symptoms Fatigue Memory and concentration...