Late-onset Alzheimer's disease (LOAD) APOE-ε4/ε4 and Brain Health: How a Mediterranean-Keto Approach Can Reduce Risk
Related to: Impact of APOE , Klotho, and sex on cognitive decline with aging https://www.pnas.org/doi/10.1073/pnas.2416042122 Understanding the APOE-ε4/ε4 Genotype The APOE (Apolipoprotein E) gene plays a crucial role in cholesterol metabolism and brain function . It comes in three common forms: ε2, ε3, and ε4 . If you have inherited two copies of the ε4 allele (APOE-ε4/ε4) , you may have an increased risk of developing late-onset Alzheimer's disease (LOAD) and cardiovascular issues . While genetics influence disease risk, lifestyle and diet can play a powerful role in reducing this risk . Research suggests that dietary choices significantly impact brain aging, inflammation, and cholesterol levels —factors that are especially relevant for APOE-ε4 carriers . One of the most effective approaches for brain health is a Mediterranean or keto-like diet that is low in processed carbohydrates . This dietary pattern combines the best of both worlds : the heart-healthy, anti-inflammator...