What drugs can damage mitochondria?
Several classes of drugs have been identified as potentially damaging to mitochondria. The damage can occur due to various mechanisms, such as disrupting the mitochondrial respiratory chain, causing oxidative stress, or impacting mitochondrial DNA. Here are some notable examples: Antiretroviral Drugs : Used in the treatment of HIV/AIDS, certain antiretroviral drugs, particularly those belonging to the class of nucleoside reverse transcriptase inhibitors (NRTIs), such as zidovudine (AZT) and didanosine (ddI), can interfere with mitochondrial DNA replication. Statins : While statins are widely used for lowering cholesterol, they can sometimes impair mitochondrial function. This is mainly through their effect on coenzyme Q10, a key component of the mitochondrial respiratory chain. Antibiotics : Certain antibiotics, especially those belonging to the aminoglycoside family (e.g., gentamicin) and tetracyclines (e.g., doxycycline), can be toxic to mitochondria, as they can inhibit mitochondria...