Case Report: Detection of TP53 (17p13) Deletion in a Patient with Suspected B-Cell Non-Hodgkin Lymphoma Using Fluorescence In-Situ Hybridization (FISH)
Abstract We report a case of a patient with a suspected B-cell lymphoproliferative disorder in whom fluorescence in-situ hybridization (FISH) analysis revealed a monoallelic deletion of the TP53 locus at 17p13. This finding has significant prognostic and therapeutic implications, as TP53 deletions are associated with poor response to conventional therapies and more aggressive disease behavior in chronic lymphocytic leukemia (CLL) and other B-cell non-Hodgkin lymphomas (NHL). This case highlights the critical role of cytogenetic analysis in the diagnostic and therapeutic approach to B-cell malignancies. Deletions at the TP53 locus in chromosome band 17p13 are found in a number of non-Hodgkin lymphomas (follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia) Introduction Chromosomal abnormalities play a pivotal role in the pathogenesis, classification, and prognosis of B-cell lymphoproliferative disorders. Among these, deletions involving...