Q and A: about health and research

Introduction In my ongoing battle with severe immunodeficiency-related symptoms, my search for answers began in earnest in 2010, when DNA testing confirmed mutations in JAK1 and JAK2. This pivotal discovery marked the start of my journey to uncover the most effective diagnostic tests, medications, and—most critically—gain a thorough understanding of their potential side effects. Over the decades, I have navigated a complex and challenging medical history, including long-term cortisol use for psoriasis since 1970, hydrocortisone therapy for adrenal insufficiency since 1979. Each of these experiences has shaped my understanding of immunodeficiency and its far-reaching impact on overall health. In 2016, I experienced a life-threatening complication following L4-L5 spinal surgery, which resulted in sepsis caused by a rare and unusual bacteremia involving Staphylococcus epidermidis , Peptostreptococcus species, Staphylococcus caprae , and Corynebacterium species. Since then, I have faced ...