Adrenal Insufficiency: The Consequences, Symptoms, and Thyroid Interaction
Important Update: Adrenal Insufficiency in Adults A Review - Published Online: June 16, 2025 by: https://jamanetwork.com/journals/jama/fullarticle/2835391?guestAccessKey=3b2c8ce2-cda4-4242-89cb-4459d7c7abd4&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=etoc-tfl_&utm_term=082625 Introduction Adrenal insufficiency, characterized by inadequate cortisol production, is a serious and potentially debilitating condition. Despite its significant impact on health and quality of life, diagnosis and effective long-term management can remain challenging. Since November 1979, I have struggled with this life-altering condition without satisfactory resolution, raising concerns about whether low cortisol and its consequences receive sufficient attention, particularly in Germany. Cortisol is regulated through the hypothalamic-pituitary-adrenal (HPA) axis , the body's central stress-response system. As described by Herman et al. in Comprehensi...