From Autoimmunity to Oncology: How a Lupus-Derived Antibody Could Help Fight Cancer
Related publication: A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells https://www.science.org/doi/10.1126/scisignal.adk3320 In a groundbreaking study titled “A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells,” researchers have identified a novel way to weaponize the immune system against cancer — using a molecule that originally plays a role in the autoimmune disease lupus. The antibody, known as 4H2 , was isolated from patients with systemic lupus erythematosus (SLE) , an autoimmune condition characterized by chronic inflammation and overactivation of immune responses. While lupus is usually associated with the immune system attacking healthy tissue, the very mechanisms that make lupus dangerous may also hold the key to unlocking new cancer therapies. Harnessing a Lupus Antibody to Activate Tumor Immunity Chen et al....