Addison's Disease vs Cushing Syndrome, carbohydrates and Psychological Symptoms
Both Addisons disease and Cushing’s syndrome involves the adrenal glands but represent opposite ends of the cortisol spectrum. 1. Adrenal Gland Involvement Addison’s Disease (Adrenal Insufficiency): Characterized by underproduction of cortisol (and often aldosterone). Common causes include autoimmune destruction , infections (e.g., tuberculosis), or genetic disorders . Primary adrenal insufficiency may also cause hypercalcaemia , likely due to volume depletion and reduced renal calcium excretion . Cushing’s Syndrome: Defined by overproduction of cortisol. Causes include pituitary tumors (Cushing’s disease) , adrenal tumors , or prolonged use of corticosteroids (iatrogenic Cushing’s). 2. Hormonal Imbalance and Physical Manifestations Feature Addison’s Disease Cushing’s Syndrome Cortisol Levels Low High Aldosterone Often low Normal or suppressed ...