Mast Cell Activation (MCA), Fibromyalgia, and Ehlers-Danlos Syndrome (EDS): The Overlapping Connection
Understanding Mast Cell Activation Syndrome (MCAS): Symptoms, Testing, and Overlapping Conditions Mast Cell Activation Syndrome (MCAS) is a complex and often underdiagnosed condition in which mast cells—a type of immune cell—release excessive amounts of chemical mediators, such as histamine, prostaglandins, and cytokines. These mediators affect multiple body systems and can lead to a wide range of chronic, fluctuating symptoms. What Are Mast Cells? Mast cells are immune cells found in connective tissues throughout the body, particularly in the skin, lungs, gastrointestinal tract, and blood vessels. Their normal role is to protect the body from allergens, infections, and injury. However, in MCAS, mast cells become abnormally reactive and release mediators too easily or excessively. Skin-Related Symptoms of MCAS The skin is one of the most commonly affected organs in MCAS. Symptoms can range from mild to severe and are often mistaken for common dermatological issues. Itching (p...