Hypocomplementemic Urticarial Vasculitis Syndrome and Chronic Urticaria
Introduction Urticaria, commonly known as hives, is a frequent dermatological condition characterized by transient wheals, itching, and sometimes angioedema. While most cases are benign and self-limited, certain forms of urticaria may signal a more complex underlying disease. Two clinically important conditions that present with persistent urticarial lesions are chronic urticaria (CU) and hypocomplementemic urticarial vasculitis syndrome (HUVS) . Although they may appear similar clinically, these disorders differ significantly in pathophysiology, diagnostic criteria, systemic involvement, and management. Proper differentiation is critical because HUVS represents a systemic autoimmune vasculitis with potentially serious organ involvement, whereas chronic urticaria is primarily a mast cell–mediated skin disorder. Chronic Urticaria Definition and Epidemiology Chronic urticaria is defined as recurrent episodes of hives, angioedema, or both lasting more than six weeks . Symptoms ofte...