Q and A: about health and research

ME/CFS is often used as a broad diagnostic category, but in some cases underlying medical conditions may remain partially investigated or overlooked.    Commonly associated factors may include viral infections, post-exertional malaise (PEM), postural orthostatic tachycardia syndrome (POTS), fibromyalgia-like pain, immune or vascular abnormalities, neuroinflammation and/or encephalitis, possible glymphatic or lymphatic system dysfunction, and possible syringomyelia. Further research, including head and torso MRI imaging, comprehensive hematological and endocrinological testing, and evaluation of genetic or inherited markers, may help clarify underlying mechanisms and improve diagnostic understanding. At the same time, important conditions such as thyroid disease, adrenal insufficiency, lupus, hemophilia or other bleeding disorders, infections, vasculitis, and other systemic illnesses may not always be fully excluded and can coexist with or contribute to symptoms. The example...

This paper addresses:   Lactate, Capnia, and Fat Oxidation as Therapeutic Axes for SARS-CoV-2 Spike Protein-Induced Sequelae https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2794-9646 Interpretation: Post-acute COVID-19 syndrome, commonly known as Long COVID, has drawn increasing attention due to persistent symptoms that continue long after infection. Similar symptoms have also been reported in some individuals after COVID-19 vaccination. A growing body of research suggests that many of these cases involve disturbances in the body’s energy metabolism—specifically how cells produce and use energy. One theory proposes that the body’s energy system becomes disrupted at the cellular level. Mitochondria, the power producers of cells, may not function efficiently in some affected individuals. When mitochondria are impaired, the body struggles to generate energy normally. Studies also suggest that the body burns less fat for steady energy and instead relies ...