The Role of Skeletal Muscle Pathophysiology in ME/CFS and Post-COVID Syndrome
A growing body of research highlights skeletal muscle pathophysiology—specifically mitochondrial dysfunction and ionic imbalances—as a key driver of these symptoms. Emerging evidence also suggests that a subset of individuals suffering from post-COVID syndrome (PCS) may develop ME/CFS-like symptoms, referred to as PC-ME/CFS, due to shared underlying mechanisms. This article collects, summarizes, and discusses the current state of knowledge on skeletal muscle dysfunction in ME/CFS and the risk factors contributing to the development of PC-ME/CFS. The latest research update: Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system https://www.nature.com/articles/s41419-025-08162-2 " Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence " Skeletal Muscle Pathophysiology in ME/...