Ghrelin and Leptin: Key Regulators of Appetite and Energy Balance - Hunger Hormone
Ghrelin: Role: Ghrelin, often called the "hunger hormone," is produced in the stomach and signals the brain to increase appetite. Mnemonic: "GhRelin—— GROW big" reminds us of its role in stimulating hunger and promoting food intake. Leptin: Role: Leptin, known as the "satiety hormone," is produced by adipose (fat) cells and signals the brain to reduce appetite. Mnemonic: "LepTin—-Thin" highlights its function in suppressing hunger and maintaining a healthy body weight. The Paradox of Leptin Resistance Leptin Resistance: Definition: Leptin resistance occurs when the brain does not respond effectively to leptin signals despite high levels of the hormone, commonly seen in obesity. Effect: The brain continues to signal hunger, leading to increased food intake and weight gain despite adequate or excessive fat stores. Paradox: Despite high leptin levels (which should promote satiety and reduce appetite), individuals with leptin resistance contin...