Normal Pressure Hydrocephalus (NPH) and Missing White Matter
Normal Pressure Hydrocephalus (NPH) is a neurological condition marked by an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles. Unlike other forms of hydrocephalus, NPH does not lead to a significant increase in intracranial pressure. Instead, the ventricles gradually enlarge, causing pressure on surrounding brain tissue, particularly in regions responsible for motor function, cognition, and bladder control. What Causes NPH? The exact cause of NPH is often unclear, but it is generally divided into two categories: Primary (Idiopathic) NPH This form appears without any identifiable trigger. The leading hypothesis is impaired CSF resorption—meaning the brain’s natural system for reabsorbing fluid into the bloodstream is dysfunctional. The resulting fluid buildup gradually distends the ventricles. Secondary NPH Secondary NPH arises as a result of other medical conditions or events that disrupt the flow or absorption of CSF. Common causes include: Brain h...