Fever, Chills, or Body Aches and Green Unrine

By SWA

 Patients experiencing symptoms like fever, chills, or body aches after taking propofol should be checked for bacterial sepsis. Propofol can cause temporary green urine due to its metabolism in the liver, intestines, and kidneys and the production of phenol metabolites, especially when hepatic elimination is limited. Additionally, propofol, a GABA receptor agonist, can impair various functions of monocytes and neutrophils in the innate immune system, such as respiratory burst, chemotaxis, phagocytosis, and polarization. Furthermore, there is a risk of severe allergic reactions, including anaphylaxis, which is potentially life-threatening and necessitates immediate medical intervention.

Several medications, similar to propofol, can cause symptoms like fever, chills, body aches, and allergic reactions, including anaphylaxis. However, the specific combination of symptoms and effects, such as the transient green discoloration of urine and the impairment of certain immune functions, is more unique to propofol. Here are some medications that can cause similar symptoms in general:

  1. Antibiotics: Certain antibiotics can cause fever, chills, and allergic reactions. Anaphylaxis is a rare but severe reaction to some antibiotics.

  2. Biologic agents (e.g., monoclonal antibodies): Used in treating various conditions including cancers and autoimmune diseases, these agents can cause infusion reactions with fever, chills, and body aches.

  3. Chemotherapy drugs: These can induce similar symptoms, including fever and chills, particularly if they lead to neutropenia (low white blood cell count), increasing the risk of infections.

  4. Contrast media used in imaging studies: Some patients may experience allergic reactions, including anaphylaxis, and symptoms like fever and chills following administration.

  5. Nonsteroidal anti-inflammatory drugs (NSAIDs): Rarely, these can cause hypersensitivity reactions including anaphylaxis in sensitive individuals.

  6. Opiates: While not commonly associated with fever, opiates can cause a range of allergic reactions, including anaphylaxis in rare cases.

  7. Blood products: Transfusion-related reactions can include fever, chills, and body aches.

  8. Vaccines: Some vaccines can cause mild fever, chills, and body aches as part of the body's immune response to the vaccine.

It's important to note that the green discoloration of urine is a more specific and less common side effect, mainly associated with propofol. As for the impairment of immune cell functions, certain other medications might have immunosuppressive effects, but the specific impact on monocyte and neutrophil functions as seen with propofol might not be a common characteristic. Always consult healthcare professionals for accurate diagnosis and treatment in case of adverse drug reactions.

 

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