Disrupted Brain Signaling Caused by Inflammation

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A short explanation:

Researchers found that areas in the brain where microglia lose the receptor P2Y12R often coincide with places where blood vessels are inflamed or damaged. This suggests that microglial changes are closely linked to vascular inflammation in the brain. When blood vessels become inflamed, less oxygen and nutrients reach neurons, and inflammatory molecules can leak into the surrounding brain tissue. In response, microglia become activated and alter their normal behavior, which can disrupt the signaling between neurons. These changes interfere with how neurons communicate with each other, leading to cognitive symptoms. As a result, people may experience slow thinking, poor concentration, memory issues, and mental fatigue. Therefore, brain fog is often thought to arise from disrupted brain signaling caused by inflammation and reduced blood flow in the brain’s blood vessels. 

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Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19

https://www.nature.com/articles/s41593-025-01871-z

© 2000-2030 Sieglinde W. Alexander. All writings by Sieglinde W. Alexander have a fife year copy right. Library of Congress Card Number: LCN 00-192742 ISBN: 0-9703195-0-9  

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